Dental Caries: A review of pathogenesis and genetically linked predispositions
Bacteria are small unicellular organisms that can cause an array of human diseases. They can take on a variety of shapes and sizes and can infect through many different modes of transfer. Streptococcus mutans is a spherical, Gram-positive bacterium that is responsible for causing dental caries. This disease is characterized by the breakdown of calcified tooth tissue, and is known more commonly as “cavities”. Studying and understanding the pathogenesis of a disease such as dental caries is helpful for medical professionals to recognize and treat the disease.
Besides understanding the exact mechanisms through which S. mutans invades and infects, it is also worth exploring any genetic predispositions for dental caries. The completion of the Human Genome Project has allowed researchers to sequence complete human gene extracts. With this information, researchers have been able to determine which genes and proteins are responsible for resistance or susceptibility to caries. Alterations to protein expression can lead to modifications in enamel structure, immune response, and sugar metabolism. Any of these modifications make one increasingly susceptible to disease.
Understanding pathogenesis and knowing genetic risk factors for diseases are two powerful weapons in combatting against them. Preventative measures should be taken when fighting against dental caries. Vaccines have been developed with some success, but perhaps the greatest method of prevention rests in low sugar diets and the daily practice of brushing.
BIOL 499, Capstone
Paul Allee
P103
10 – 10:30 AM